BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver InflammationSummary
Background & Aims: Breast regression protein 39 (BRP39) (Chi3L1) and its human homolog YKL-40, is an established biomarker of liver fibrosis in nonalcoholic steatohepatitis (NASH) patients, but its role in NASH pathogenesis remains unclear.We recently identified Chi3L1 as one of the top up-regulated genes in mice with inducible gain-of-function